Table 20. p-Values of the distributions of PPI network features between essential and viable datasets.

p-values were computed using Mann–Whitney U test.

PPI Network Features	Known (K) Network	Known-Predicted (KP) Network
Degree	8.2×10−16	4.1×10−63
Average shortest path length	8.56×10−26	1.15×10−260
Betweenness centrality	1.89×10−15	3.21×10−12
Clustering coefficient	9.7×10−4	1.2×10−39
Closeness centrality	1.33×10−28	5.77×10−266