More complex proteins, with greater length, more long introns and exons, and more transcripts |
Simpler, shorter gene structure |
Higher expression levels at all stages before juvenile |
Lower expression levels at all stages before juvenile |
Older evolutionary age |
Younger evolutionary age |
Transferase or ligase enzyme activity |
Hydrolase enzyme activity |
Phosphorylated and acetylated proteins |
N- glycosylated proteins |
Intracellular proteins |
Secreted proteins |
Nuclear proteins |
Extracellular and membrane-bound proteins |
Involved in developmental processes, such as: morphogenesis, proliferation, transcription, differentiation and cell division |
Involved in extracellular interactions, such as: responses to stimuli, immune system, aging, signal transduction and transport |
DNA binding functions |
Transport functions |
Central positions in protein-protein interaction networks |
Peripheral positions in protein-protein interaction networks |
Less likely to be housekeeping or tissue enriched genes |
More likely to be housekeeping or tissue enriched genes |