Table 3. Gene-level p-values for the association tests of candidate genes with SBP in the genetic analysis 19 data analysis.

Gene	SKAT		SKAT-O		Burden		SMT
	All SNVs	Rare SNVs	All SNVs	Rare SNVs	All SNVs	Rare SNVs	All SNVs	Rare SNVs
INSR	0.51	0.73	0.72	0.76	0.27	0.70	0.14	0.07
RRAS	0.33	0.32	0.49	0.46	0.59	0.34	0.26	0.18
ZNF101	0.94	0.93	0.91	0.87	0.97	0.72	0.98	0.97
ELAVL3	0.46	0.44	0.29	0.42	0.12	0.27	0.76	0.74
RGL3	0.21	0.13	0.32	0.22	0.46	0.22	0.03	0.02
AMH	0.30	0.24	0.46	0.38	0.65	0.73	0.18	0.12
DOT1L	0.59	0.60	0.78	0.79	0.43	0.73	0.70	0.51
PLEKHJ1	0.59	0.50	0.79	0.72	0.33	0.67	0.18	0.13
SF3A2	0.50	0.36	0.70	0.54	0.41	0.97	0.23	0.15

Unadjusted p-values from gene-level genetic association analysis of all common and rare SNVs (“all SNVs”), and only rare SNVs (“rare SNVs”) in 9 candidate genes with SBP. Adjustments for multiple testing of all SNVs in SMTs in a gene were done using the BH-correction.