A. Estimated US health department return on investment for tuberculosis (TB) contact investigations for latent TB infection rates of 1.1% and 1.4%, at risks of progression to TB disease of 5.25%, 7.35%, and 10.25%. B. Estimated US health department return on investment for tuberculosis (TB) contact investigations for latent TB infection rates of 19% and 24%, at risks of progression to TB disease of 5.25%, 7.35%, and 10.25% aLTBI = latent tuberculosis Infection bHD = health department cTBCI = tuberculosis contact investigation dROI = Return on Investment.