Table 1.
Characteristics of study participants.
| Controls (n=229) N (%) |
ALS Cases (n=163) N (%) |
MND Cases (n=193) N (%) |
|
|---|---|---|---|
| Age (years), mean ± (SD) | 63.4 (9.9) | 62.9 (10.8) | 63.5 (10.8) |
|
| |||
| Quartiles*, N (%) | |||
|
| |||
| 34–57 | 65 (28) | 41 (25) | 48 (25) |
| 58–64 | 58 (25) | 48 (29) | 55 (28) |
| 65–71 | 50 (22) | 30 (18) | 32 (17) |
| 72–84 | 56 (24) | 44 (27) | 58 (30) |
|
| |||
| Gender, N (%) | |||
|
| |||
| Male | 216 (94) | 160 (98) | 190 (98) |
| Female | 13 (6) | 3 (2) | 3 (2) |
|
| |||
| Race and Ethnicity, N (%) | |||
|
| |||
| Non-Hispanic White | 201 (88) | 152 (93) | 179 (93) |
| Other | 28 (12) | 11 (7) | 14 (7) |
|
| |||
| Cigarette Smoking, N (%) | |||
|
| |||
| Ever | 154 (67) | 104 (65) | 122 (65) |
| Never | 75 (33) | 56 (35) | 67 (35) |
| Missing | 0 | 3 | 4 |
|
| |||
| Diagnosis, N (%) | |||
|
| |||
| Clinically definite ALS | - | 31 (19) | 31 (16) |
| Clinically probable ALS | - | 108 (66) | 108 (56) |
| Clinically possible ALS | - | 24 (15) | 24 (12) |
| Progressive muscular atrophy | - | - | 30 (16) |
|
| |||
| Site of Onset, N (%) | |||
|
| |||
| Spinal | - | 127 (78) | 156 (81) |
| Bulbar | - | 36 (22) | 37 (19) |
|
| |||
| Diagnostic Delay (years), N (%) | |||
|
| |||
| ≤ 1 | - | 88 (54) | 100 (52) |
| > 1 | - | 75 (46) | 93 (48) |
|
| |||
| Collection Delay (months)†, N (%) | |||
|
| |||
| ≤ 13 | - | 76 (47) | 91 (47) |
| > 13 | - | 87 (53) | 102 (53) |
|
| |||
| ALS Functional Rating Scale-Revised Score†, N (%) | |||
|
| |||
| ≤ 29 | - | 82 (51) | 92 (49) |
| > 29 | - | 78 (49) | 97 (51) |
| Missing | - | 3 | 4 |
Abbreviations: SD, standard deviation.
*
Categorized at quartiles among the controls.
†
Dichotomized at the median among ALS cases.