Table A.11.
Parameters adjusted in one multivariate sensitivity analysis*
| Input parameter | Parameter values explored
|
|
|---|---|---|
| Base case value US$ | Alternative values US$ | |
| 3HP medication cost per dose | 12.31 | 5, 25 |
| Directly observed therapy cost per dose | 17.76 | 0, 35 |
| TB hospitalization probability, % | 49 | 25 |
| Proportional change in risk of progression to tuberculosis disease, % | 100 | 50, 150 |
| Annual QALY loss from LTBI treatment | 0.03 | 0 |
| Cost of follow-up clinic visit | 27.92 | 20, 35 |
*
Each parameter was assigned to each of the values given below (324 total simulations, one for each combination of parameters). All other parameter values were maintained at their base case levels. Each simulation included 50 000 individuals for each regimen.
3HP = 12-dose regimen of weekly rifapentine plus isoniazid; QALY = quality-adjusted life years; LTBI = latent tuberculous infection.