Fig. 1.
Structure and composition of native and decellularized lungs. A) Photograph of native rat lungs. B) Photograph of lungs decellularized with Triton/SDC. C) Photograph of lungs decellularized with pH 12.4, CHAPS-based decellularization fluid (CHAPS). D) Transmission electron micrograph (TEM) of native rat lungs. E) TEM of rat lungs decellularized with Triton/SDC. F) TEM of rat lungs decellularized with CHAPS. D–F scale bars = 2 μm. G) Bar chart showing the relative compositions of native and decellularized lungs, as assessed by quantitative ECM proteomics.