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. Author manuscript; available in PMC: 2017 Aug 23.
Published in final edited form as: Nat Genet. 2016 Dec 5;49(1):125–130. doi: 10.1038/ng.3738

Table 1.

SNPs associated with ectopic fat traits (p<5×10−8)1. Association statistics were obtained using a sample-size weighted fixed-effects meta-analysis implemented in METAL.18,19

Locus2 Trait Strata Lead SNP Chr SNPID Position A13 A24 Freq A15 N Z score P-value6
Fat Volume Traits7,8
NEW
 ENSA PATadjHtWt ALL rs6587515 1 rs6587515 148875512 a g 0.09 11027 −5.94 2.8×10−9
 GRAMD3 VATadjBMI WOMEN rs10060123 5 rs10060123 125711809 a c 0.23 9623 5.47 4.5×10−8
 EBF1 PATadjHtWt ALL rs1650505 5 rs1650505 157962312 a g 0.24 11566 −6.10 1.0×10−9
PAT ALL 5 rs2434264 157954781 t g 0.61 11614 5.93 3.0×10−9
 RREB1 VATadjBMI ALL rs2842895 6 rs2842895 7051315 c g 0.50 17297 5.72 1.1×10−8
 GSDMB SAT WOMEN rs2123685 17 rs2123685 35307415 t c 0.94 7137 5.52 3.4×10−8
KNOWN
 TRIB2 PATadjHtWt ALL rs10198628 2 rs10198628 12881948 a g 0.42 11572 −8.88 6.7×10−19
PATadjHtWt MEN 0.43 5466 −6.68 2.4×10−11
PATadjHtWt WOMEN 0.42 6106 −6.02 1.8×10−9
PAT ALL 0.42 11605 −7.87 3.7×10−15
 FTO SAT ALL rs7185735 16 rs7185735 52380152 a g 0.58 17812 −6.05 1.4×10−9
Fat Attenuation Traits7,8
NEW
 ATXN1 SATHU MEN rs2237199 6 rs2237199 16538000 a g 0.11 5780 5.67 1.4×10−8
Relative Fat Distribution Traits7,8
NEW
 UBE2E2 VAT/SAT ratio ALL rs7374732 3 rs7374732 23178458 t c 0.69 18205 −6.29 3.1×10−10
VAT/SAT ratio adjBMI ALL 0.69 18190 −5.64 1.7×10−8
KNOWN
 LYPLAL1 VAT/SAT ratio ALL rs6689335 1 rs6689335 217695305 t c 0.59 15214 −5.59 2.3×10−8
VAT/SAT ratio adjBMI ALL 1 rs6689335 217695305 t c 0.59 15199 −5.53 3.2×10−8
 LY86 VAT/SAT ratio ALL rs912056 6 rs912056 6681196 a t 0.35 17387 −5.96 2.5×10−9
VAT/SAT ratio adjBMI ALL 0.35 17372 −5.98 2.3×10−9
1

SNPs are grouped by ectopic fat trait and are listed by new discoveries and then previously identified loci. Any association attaining genome-wide significance (p<5×10−8) is listed.

2

Conventional locus name based on closest gene in the region

3

A1 is the coded allele

4

A2 is the non-coded allele

5

FreqA1 is the allele frequency of Allele1

6

P-values are double genomic control corrected

7

European and African ancestry cohorts contributed to all ectopic fat traits; Chinese and Hispanic ancestry cohorts contributed only to pericardial volume traits

8
Abbrevations:
  • SAT - Subcutaneous Adipose Tissue Volume
  • VAT - Visceral Adipose Tissue Volume
  • PAT - Pericardial Adipose Tissue Volume
  • SATHU - Subcutaneous Adipose Tissue Attenuation
  • VATHU - Visceral Adipose Tissue Attenuation
  • VAT/SAT ratio - Visceral to Subcutaneous Adipose Tissue Volume Ratio
  • adjBMI - Model Adjusted for BMI
  • adjHtWt - Model Adjusted for Height and Weight