Table 1.
Baseline characteristics of the four cohorts used in this study
| Characteristic | TwinGenea | ULSAM | PIVUS | KORA S4b |
|---|---|---|---|---|
| N (total) | 1549 (subcohort) 81 (case-cohort) | 1138 | 970 | 855 |
| Prevalent diabetes | 192 (12) | 220 (19) | 113 (12) | – |
| IFG | 444 (29) | 249 (22) | 337 (35) | 325 (38) |
| No. of incident events of type 2 diabetes | 122 | 78 | 70 | 88 |
| Age (years) | 68.0 ± 8.1 | 71.0 ± 0.6 | 70.2 ± 0.2 | 63.1 ± 0.4 |
| % female sex | 42 | 0 | 50 | 49 |
| % current smoker | 13 | 20 | 10 | 49 |
| BMI (kg/m2) | 26.0 ± 3.9 | 26.3 ± 3.4 | 27.1 ± 4.3 | 28.1 ± 4.0 |
| Waist circumference (cm) | 92.8 ± 11.8 | 94.9 ± 9.6 | 91.2 ± 11.6 | 94.5 ± 11.1 |
| Fasting glucose (mmol/l) | 5.7 ± 1.3 | 5.8 ± 1.5 | 5.9 ± 1.8 | 5.5 ± 0.5 |
| HDL-cholesterol (mmol/l) | 1.4 ± 0.4 | 1.3 ± 0.3 | 1.5 ± 0.4 | 1.5 ± 0.4 |
| LDL-cholesterol (mmol/l) | 3.7 ± 1.0 | 3.9 ± 0.9 | 3.4 ± 0.9 | 4.0 ± 1.0 |
| Triacylglycerol (mmol/l) | 1.3 ± 0.7 | 1.5 ± 0.8 | 1.3 ± 0.6 | 1.5 ± 0.8 |
| Systolic blood pressure (mmHg) | 141.0 ± 19.8 | 146.8 ± 18.7 | 149.1 ± 22.6 | 133.0 ± 19 |
| Diastolic blood pressure (mmHg) | 81.7 ± 10.5 | 83.7 ± 9.4 | 78.6 ± 10.2 | 80.0 ± 10 |
| % taking antihypertensive medication | 25 | 35 | 31 | 31 |
| % taking lipid-lowering medication | 17 | 9 | 16 | 11 |
Data are shown as mean ± SD for continuous variables and as n (%) for binary variables
a
Baseline characteristics are given for subcohort of TwinGene
b
Replication cohort, individuals with prevalent type 2 diabetes are excluded