Table 4.

Association of the T allele CYP7A1 variant rs8192870 or its corresponding C allele of the proxy rs2326077 (r² = 0.881) with metabolic traits

Phenotype	Study	Year	β	SE	p value	No. of controls	No. of cases	Unit
Type 2 diabetesa	Morris et al (2012) [22]	2012	−0.033	0.012	8.1 × 10−3	114,981	34,840	log(OR)
Fasting glucosea	Dupuis et al (2010) [36]	2010	−0.004	0.002	0.07	133,010	0	mmol/l
Log(fasting insulin)a	Dupuis et al (2010) [36]	2010	−0.002	0.003	0.41	108,557	0	pmol/l
2 h fasting glucosea	Dupuis et al (2010) [36]	2010	−0.010	0.011	0.37	42,854	0	mmol/l
LDL-cholesterola	Global Lipids Genetics Consortium (2013) [41]	2013	0.034	0.004	5.0 × 10−17	172,996	0	IVNT
Triacylglycerolsa	Global Lipids Genetics Consortium (2013) [41]	2013	0.018	0.003	5.4 × 10−7	177,766	0	IVNT
HDL-cholesterola	Global Lipids Genetics Consortium (2013) [41]	2013	0.004	0.004	0.22	187,069	0	IVNT
BMI	Locke et al (2015) [42]	2015	0.001	0.004	0.88	235,991	0	INVT
Waist-to-hip ratio	Shungin et al (2015) [43]	2015	0.006	0.004	0.19	144,548	0	INVT

Results are extracted from the largest available GWAS datasets

^aMetabochip proxy rs2326077

IVNT, inverse normal transformed trait