Table III.

Previous cancer and subsequent risk of amyotrophic lateral sclerosis (ALS), a nested case-control study in Sweden, 1987–2009

	Controls (n=27405)	ALS (n=5481)	OR (95% CI) a
No cancer	24635	4926	Reference
Any cancer
<1 yr before index date	270	81	1.50 (1.17–1.92)
≥1 to <2 yrs before index date	243	57	1.17 (0.88–1.57)
≥2 yrs before index date	2257	417	0.92 (0.82–1.03)
Melanoma
<1 yr before index date	6	6	5.13 (1.65–15.9)
≥1 to <2 yrs before index date	8	2	1.24 (0.26–5.82)
≥2 yrs before index date	129	27	1.03 (0.68–1.56)
Prostate cancer
<1 yr before index date	71	28	1.97 (1.27–3.06)
≥1 to <2 yrs before index date	66	18	1.37 (0.81–2.33)
≥2 yrs before index date	402	71	0.88 (0.68–1.14)
Brain tumor
<1 yr before index date	5	4	4.25 (1.14–15.9)
≥1 to <2 yrs before index date	2	0	-
≥2 yrs before index date	62	11	0.88 (0.46–1.68)

^aOR, odds ratio;

CI, confidence interval; ORs were adjusted for age, sex, education level, region of area and socio-economic status