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Identification of a single nucleotide polymorphism in Tyro3 associated with the anx phenotype. (A) In mice carrying the anx mutation, a C-to-T mutation in Tyro3 converts an arginine-to-tryptophan at amino acid 7 in Tyro3 protein (R7W-Tyro3) and (B) eliminates an NlaIV site. (C) Mice with the anx phenotype are homozygous for R7W-Tyro3 (n=176), whereas R7W-Tyro3/+ (n=584) and +/+ (n=235) mice appear normal.
