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. 2017 May 1;10(5):559–579. doi: 10.1242/dmm.027730

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Intracellular sequestration and aggregation of the chemokine receptor Cxcr4 and its ligands, Cxcl14 and Cxcl12, in motoneurons of SLICK-H::Ranbp2^flox/flox mice. (A,B) Representative images of Cxcr4, Cxcl14 and Cxcl12 subcellular localizations in YFP⁺ motoneurons in different genotypes. +/+ mice have weak immunostaining and a diffuse cellular distribution of Cxcr4 and Cxcl14 (A,a-e) and Cxcl12 (B,a-e) in YFP⁺ motoneurons of the anterior horn, whereas there is intracellular colocalization, sequestration and aggregation of Cxcr4 with Cxcl14 (A,f-j) and Cxcl12 (B,f-j) in YFP⁺ motoneurons of −/− mice. (f′-j′) Magnified images of the outlined regions indicated in f-j. (C) There are no signs of overt glyosis and microglia activation in the anterior horns at d10 (day 10) post-tamoxifen administration, as shown by the absence of GFAP⁺ and Cd11b⁺ immunostaining between genotypes. Scale bars: 25 µm. −/−, SLICK-H::Ranbp2^flox/flox; +/+, SLICK-H::Ranbp2^+/+. Arrows indicate intracellular aggregate or deposit foci.