Fig. 6.

PD midbrain autopsies contain cytoplasmic and neuritic aggregates. Tissue sections (5 μm thick) from individuals with PD were stained with anti-complexin 1 (Acris) or double stained with anti-complexin 1 and anti- SNCA antibodies. (A-C) Neurons in the substantia nigra exhibiting Lewy body-like structures mildly stained with anti-complexin 1 (arrowheads). (D) Complexin 1 immunopositive Lewy neurite-like structure (asterisks) in the medulla at the level of the motor vagus nucleus. (E-H) Double immunostaining depicting possible co-localization of α-synuclein (SNCA; green) and complexin 1 (red), only after maximal exposure and contrast adjustment in the red channel. Sections were counterstained with Hoechst dye.