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. 2017 May 2;127(6):2339–2352. doi: 10.1172/JCI92217

Figure 1. hCD1Tg HJ1Tg Apoe–/– mice spontaneously develop skin inflammation.

Figure 1

(A) Mice were weighed beginning at 2.5 months of age up to 5.5 months of age. Percentage change in body weight was calculated over the time period (n = 4–10). (B) Mice were monitored from 20 to 25 weeks for the development of dermatitis and percentages of incidence recorded (left); epidermal thickness was also quantified (right; n = 11–14). (C and D) Representative H&E (C) and Ki67 (D) staining of skin sections from 6-month-old mice. Scale bars: 100 μm. (E) mRNA analysis of S100a proteins in the skin of indicated mice (n = 3–5). (F) Representative oil red O–stained sections from aortic root of Apoe–/– and hCD1Tg HJ1Tg Apoe–/– mice (left panel) are shown, and bar graph depicts the mean + SEM of aortic root plaque area from indicated mice (n = 8–9). ***P < 0.005; **P < 0.01; *P < 0.05. Statistical analyses were performed using 1-way ANOVA followed by Bonferroni’s post-hoc test for 3-group comparisons and Student’s t test for 2-group comparisons.