Figure 3. Biomatrices placed directly on pancreatic tumors provide an effective delivery platform for CAR-programmed T cells.

(A) Bright-field microscopy of stimulatory microspheres incorporated into the biopolymer scaffold and a depiction of the composition of the microspheres. Scale bar: 70 μm. (B) This series of images illustrates our methodology: (i) biopolymer scaffold; (ii) seeding of tumor-reactive T cells into the device; (iii) incision; (iv) orthotopic KPC pancreatic tumor; (v) implantation of a T cell–loaded device; (vi) wound closure; (vii–ix) sustained release of tumor-reactive T cells.