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. 2017 May 15;127(6):2118–2132. doi: 10.1172/JCI92001

Figure 3. Antiinflammatory drugs administered during epileptogenesis prevent disease progression in electrical SE–exposed rats.

Figure 3

(A) Progression index (the ratio between the number of seizures at 4.5 months and at 2.5 months after SE) in vehicle- and drug-treated rats. Value equivalent to 1 defines lack of progression. Data are shown as mean ± SEM (n = 9 rats each group). *P < 0.05 versus vehicle, Mann-Whitney U test. Raw data are shown in Supplemental Table 1. (B) Odds ratio (0.24; P = 0.008) indicates that drug-treated rats evaluated at 2.5 months have a 76% reduced risk of developing seizures at 4.5 months versus vehicle-treated rats. Treatment included anakinra+BoxA+ifenprodil (SE+drug) (see Methods; Supplemental Figure 5A). OR, odds ratio.