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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Nanomedicine. 2017 Jan 20;13(4):1353–1362. doi: 10.1016/j.nano.2017.01.009

Figure 1.

Figure 1

Drug-loaded, iron-stabilized micelles self-assemble during formulation to form nanoparticles composed of an amphiphilic poly(ethylene glycol) corona, hydroxamic acid stabilizing middle block, and hydrophobic core block for drug encapsulation. Hydrophobic amino acids sequester drugs in the core of the micelle without the need for covalent attachment which requires chemical or enzymatic cleavage for release. Iron chelates with the hydroxamic acid moieties forming dative bonds among polymer strands to stabilize the micelle for intravenous administration and subsequent dilution. The final drug product is a lyophilized powder for reconstitution in saline for administration.