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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Nanomedicine. 2017 Jan 20;13(4):1353–1362. doi: 10.1016/j.nano.2017.01.009

Figure 4.

Figure 4

MR imaging of iron-stabilized micelles in mouse subcutaneous xenograft models. (A) Time-course T1-weighted MRI of HCT116 mouse xenograft following IV administration of SN-38-loaded, iron-stabilized micelle formulation (IT-141). Tumor is identified by red circle in both panel (A) and (B). Signal peaks around 24-48 hours and is mainly cleared by 168 hours (B). Time-course T1-weighted MRI compared to T2-weighted MRI in HCT116 xenograft model. Pre-dose and 48 hours MRI image of HCT116 (C) and NCI-H460 (D) mouse xenograft following IV administration of epothilone D-loaded, iron-stabilized micelle formulation (IT-147).