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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: Nanomedicine. 2017 Jan 20;13(4):1353–1362. doi: 10.1016/j.nano.2017.01.009

Figure 5.

Figure 5

Drug-loaded, iron-stabilized micelles increase anti-tumor efficacy compared to free drug in subcutaneous xenograft models. Body weights do not change more than 20% from starting weight in efficacy studies. Relative tumor volume in HCT116 colorectal model treated with IT-141 compared to irinotecan (A), HT-29 colorectal adenocarcinoma model treated with IT-141 (B), and HCT116 colorectal model treated with IT-147 (C). Arrows indicate dosing days. (D, E, F) Percent body weight change during HCT116 efficacy study using IT-141 (D), HT-29 efficacy study using IT-141 (E), and HCT116 efficacy study using IT-147 (F).