Skip to main content
. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Mar 22;234(12):1881–1889. doi: 10.1007/s00213-017-4596-7

Fig 2. Naloxone challenge.

Fig 2

Peak (mean ± SD) ACTH (left) and cortisol (right) following saline (0 μg/kg) and naloxone (125 and 375 μg/kg) challenges. Both doses of naloxone increased ACTH and cortisol compared to saline (a: p < 0.05). The peak cortisol response to naloxone was greatest during the social housing phase (b: p < 0.05) when compared to both individual housed phases. Circles: dominant animals, triangles: non-dominant animals.