Figure 1.

MRI and OCT findings: (a) case 1: FLAIR imaging showing a lesion in the left occipital white matter (red inset, arrow) associated with focal volume loss (red inset, arrowheads). OCT imaging revealed homonymous, hemi-macular GCIP thinning and MMP (red insets); (b) case 2: MPRAGE image showing a T1-hypointense lesion in the right occipital white matter extending into the adjacent striate cortex, which appears atrophic relative to the contralateral side (red inset). The lesion appeared T2 hyperintense on FLAIR imaging (green inset), while OCT showed homonymous, hemi-macular GCIP thinning and MMP; and (c) case 4: FLAIR image showing a right periventricular T2 hyperintensity extending into the occipital white matter in a patient who presented with left homonymous hemianopia. OCT images performed 4 years after presentation revealed hemi-macular GCIP thickness reduction without evidence of MMP.

FLAIR: fluid-attenuated inversion recovery; OCT: optical coherence tomography; GCIP: ganglion cell + inner plexiform layers; MMP: macular microcystoid pathology; MPRAGE: magnetization-prepared rapid-acquisition with gradient echo; N: nasal; T: temporal.