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Antinociceptive effects of oxycodone (left) and I2 receptor agonist phenyzoline (right) on CFA-induced mechanical hyperalgesia before, during and after twice-daily oxycodone (top) and phenyzoline (bottom) treatment. Tests during the treatment were performed on days 8 and 9. Tests after the treatment were performed on days 8 and 9 in oxycodone alone group and on days 20 and 21 in phenyzoline alone group. Ordinates, percentage of maximal possible effects; Abscissa, drug doses (mg/kg).
