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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Mar 17;234(12):1871–1880. doi: 10.1007/s00213-017-4599-4

Figure 2.

Figure 2

Antinociceptive effects of oxycodone (top) and I2 receptor agonist phenyzoline (bottom) on CFA-induced mechanical hyperalgesia before, during and after twice-daily treatment with the combination of oxycodone and phenyzoline at different proportion ratios: 1:3 (left), 1:1 (middle) and 3:1 (right). Tests during the treatment were performed on days 8 and 9. Tests after the treatment were performed on days 20 and 21 in 1:3 and 1:1 ratio groups and on days 14 and 15 in 3:1 ratio group. Ordinates, percentage of maximal possible effects; Abscissa, drug doses (mg/kg).