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Antinociceptive effects of oxycodone (top) and I2 receptor agonist phenyzoline (bottom) on CCI surgery-induced mechanical hyperalgesia before, during and after twice daily treatment with the combination of oxycodone and phenyzoline at different proportion ratios: 1:3 (left), 1:1 (middle) and 3:1 (right). Tests during the treatment were performed on days 8 and 9. Ordinates, percentage of maximal possible effects; Abscissa, drug doses (mg/kg). See Figure 2 for other details.
