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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Mar 31;234(12):1815–1828. doi: 10.1007/s00213-017-4590-0

Figure 6.

Figure 6

Timeline of experimental procedures across PNDs in Experiment 4 (a) and mean reinforcers obtained (±SEM) in Experiment 4 in male (b column) and female (c column) rats that had access to saline (0.00 mg/kg, IV, Sal) or a given dose of nicotine (0.015 or 0.03 mg/kg, IV, Nic) across acquisition on a FR1 schedule of reinforcement during sessions 1-3 and a progressive ratio schedule of reinforcement sessions 4-20 while allowed limited social contact through a mesh barrier (Soc: closed circles) or while isolated (Iso: open squares). The progressive schedule increased from an FR1 to FR2 to FR 3 depending on individual performance with the criterion for advancement of 5 reinforcers obtained within 60 min. See Table 1 for n/condition. A 4-way Session × Sex × Dose × Social Condition interaction was detected, ANOVA p <0.05. Further analyses of the interaction are shown in Figures 7 and 8.