Table 1.
Patients with Merkel cell polyomavirus-positive tumors (immunoreactive for CM2B4).
| Age (years) |
Gender | Primary Site | H3K27me3 IHC |
Tumor Stage |
Number of Mutations |
|---|---|---|---|---|---|
| 74 | F | Extremity | 1+ | 1 | ? |
| 77 | M | Extremity | 1+ | 1 | ? |
| 71 | F | Extremity | 1+ | 1 | ? |
| 77 | M | Extremity | 1+ | 1 | ? |
| 74 | F | Extremity | 1+ | 1 | None detected |
| 80 | F | Extremity | 1+ | 1 | ? |
| 78 | M | Extremity | 1+ | 1 | ? |
| 62 | M | Extremity | 1+ | 1 | ? |
| 78 | F | Extremity | 1+ | 1 | ? |
| 80 | F | Extremity | 1+ | 1 | ? |
| 85 | F | Head and Neck | 1+ | 1 | ? |
| 65 | M | Head and Neck | 1+ | 1 | ? |
| 77 | M | Trunk | 1+ | 1 | ? |
| 48 | M | Trunk | 1+ | 1 | ? |
| 75 | M | Trunk | 1+ | 1 | None detected |
| 76 | M | Trunk | 1+ | 1 | ? |
| 52 | F | Extremity | 1+ | 1 | ? |
| 75 | M | Extremity | 1+ | 2 | None detected |
| 84 | F | Extremity | 1+ | 2 | None detected |
| 65 | M | Extremity | 1+ | 2 | None detected |
| 79 | M | Extremity | 1+ | 2 | None detected |
| 80 | M | Extremity | 1+ | 2 | None detected |
| 78 | M | Extremity | 1+ | 2 | ? |
| 89 | M | Extremity | 1+ | 2 | ? |
| 74 | M | Head and Neck | 1+ | 2 | ? |
| 90 | M | Head and Neck | 1+ | 2 | None detected |
| 97 | F | Head and Neck | 1+ | 2 | None detected |
| 83 | F | Trunk | 1+ | 2 | None detected |
| 52 | M | Trunk | 1+ | 2 | None detected |
| 75 | F | Trunk | 1+ | 2 | None detected |
Abbreviations/Explanations: CM2B4 – antibody to Merkel cell polyoma virus large T-antigen.
F = female; M = male; Tumor Stage: 1 = primary tumor; 2 = locoregional (lymph node or soft tissue) metastasis; IHC = immunohistochemistry; 1 + = positive labeling in 1 – 25% of tumor cells
? = unknown (mutation analysis was not performed)