Table 2.
Patients with tumors immunonegative for Merkel cell polyomavirus (CM2B4)
| Age (years) |
Gender | Primary Site | H3K27me3- IHC |
Tumor Stage |
Histologic Type |
Number of Mutations |
|---|---|---|---|---|---|---|
| 71 | M | Extremity | 4+ | 1 | Mixed | ? |
| 74 | M | Head and Neck | 4+ | 1 | Mixed | ? |
| 67 | M | Head and Neck | 4+ | 1 | Mixed | 12 |
| 79 | M | Head and Neck | 4+ | 1 | Mixed | ? |
| 82 | M | Trunk | 4+ | 1 | Mixed | 16 |
| 70 | F | Head and Neck | 2+ | 1 | Pure | ? |
| 86 | M | Head and Neck | 2+ | 1 | Pure | 68 |
| 64 | M | Head and Neck | 1+ | 1 | Pure | ? |
| 71 | M | Trunk | 1+ | 1 | Pure | ? |
| 60 | M | Head and Neck | 1+ | 1 | Pure | 38 |
Abbreviations/Explanations: CM2B4 = monoclonal antibody to Merkel cell polyomavirus large T-antigen; F = female; M = male; Tumor stage: 1 = primary skin tumor; ? = unknown (mutation analysis was not performed); IHC = immunohistochemistry; 1+ = 1 – 25% of tumor cells are positive; 2+ = 26–50% of tumor cells are positive; 3+ = 51–75% of tumor cells positive and 4+ = 76–100% of tumor cells are positive.