Fig. 3.

Superposition of 2D ¹H-¹⁵N HSQC NMR spectra (full spectrum shown in upper panel, enlarged spectral regions depicted in lower panel) of ¹⁵N-enriched fibronectin type II module FN13 in the absence (black) and presence of an excess of human MIA (red). Resonances originating from fibronectin that experience chemical shift perturbations upon binding of MIA are labeled. For the sequence numbering scheme please refer to the experimental part.