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. 2017 Jun;102(6):1054–1065. doi: 10.3324/haematol.2016.159053

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Figure 1. — (A) Variable expression of ALDH1A1 and other aldehyde dehydrogenase (ALDH) isoforms in human acute myeloid leukemia (AML). The AML dataset from The Cancer Genome Atlas (TCGA) was analyzed for differential expression of ALDH isoforms in human AML blasts. (B) The GSE9476 dataset was analyzed for differential expression of ALDH1A1 between normal human hematopoietic cells (HSCs) and AML samples. (C) ALDH1A1 expression based on RNA-Seq analysis in LSC (white) and non-LSC (light gray) samples at diagnosis and LSC samples at relapse (black). The control is similarly analyzed normal bone marrow CD34⁺ cells (NBM HSC) (dark gray) (****P<0.0001). (D) ALDH1A1 expression using RNA-Seq analysis between paired diagnostic and relapsed LSC samples. (each symbol represents a different patient).