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. 2017 May 31;7:2501. doi: 10.1038/s41598-017-02714-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Stroke-mediated DLS infarction reduces GABAergic inputs to DMS-projecting SNc neurons. (a) Schematic of proposed changes in striatal and midbrain neurons after DLS infarction. The death of GABAergic DLS neurons (1) may disinhibit dopamine neurons (2) that project to the DMS, leading to increased activity of these neurons (3, 4). (b) Representative sIPSC traces in DMS-projecting SNc neurons on the Non-Isch and Isch sides. Scale bars: 50 ms, 100 pA. (c) Stroke-induced DLS infarction reduced the frequency and amplitude of sIPSCs in DMS-projecting SNc neurons. Left, bar graphs summarizing the average sIPSC frequencies. *p < 0.05. Right, bar graphs displaying the average amplitudes. *p < 0.05, t test. n = 12 neurons from 4 rats (Non-Isch) and 12 neurons from 5 rats (Isch) for both left and right graphs. (d) Stroke-induced DLS infarction resulted in lower GABA-induced currents in DMS-projecting SNc neurons. Left, changes in the holding current in DMS-projecting SNc neurons on the contralesional non-ischemic (Non-Isch) and ipsilateral ischemic (Isch) sides. Right, bar graphs summarizing the averaged GABA currents in SNc neurons on both sides. *p < 0.05, t test. n = 9 neurons from 5 rats per group.