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. 2017 May 31;7:2551. doi: 10.1038/s41598-017-02700-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional analysis of putative GATA-1 element in IRF-3 promoter. (a) Relative luciferase activities of truncated plasmids of IRF-3 promoter. (b) Putative consensus binding sites of transcription factors were identified by TFSEARCH ver.1.3 and Matlnspector. (c) Nucleotide sequences of the original and GATA-1 element deleted version of pGL3-149 plasmid (pGL3-Del). (d) The promoter activity of pGL3-149 and pGL3-Del in A549 cells. Error bars represent the mean ± S.D. (n = 3). Statistical analyses were done using Student’s-t tests. *p < 0.05; **p < 0.01; ****p < 0.0001 compared with control.