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. 2017 May 31;7:2551. doi: 10.1038/s41598-017-02700-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of GATA-1 protein expression upregulates IRF-3 transcriptional activity. (a) pGL3-149 and pGL3-Del were transfected with GATA-1 siRNA or control siRNA into cells. Relative luciferase activity and (b) mRNA expression were detected at 24 h post-transfection. Statistical analyses were done using Student’s-t tests (*p < 0.05; **p < 0.01). (c) A549 cells were transfected with different dose of GATA-1 siRNA for 48 h. IRF-3 and GATA-1 proteins were analyzed by Western blot. The full-length blots were presented in Supplementary Figure S3.