Table 4.
Metabolites with differential concentrations by Hhip genotype (Hhip+/− versus Hhip+/+) in cigarette smoke-exposed mice.
| Sample Type/Metabolite | Log2 (Fold change)* | P-value† |
|---|---|---|
| Plasma | ||
| C30:1 phosphatidylcholine | −1.51 | 0.04 |
| Pantothenate | 1.16 | 3.6 × 10−3 |
| Sorbitol | 1.39 | 0.05 |
| Urine | ||
| Alpha-hydroxybutyrate | −1.22 | 0.04 |
| C5 carnitine | −1.82 | 0.03 |
| Cotinine | −1.89 | 0.03 |
| Creatine | 1.17 | 0.03 |
*Negative values indicate lower concentration in Hhip+/− heterozygotes (minimum 2x fold change).
†Student’s t-test.
No metabolites met the thresholds for significance in lung tissue.