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. 2017 May 31;7:2520. doi: 10.1038/s41598-017-02782-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum miRNA profiles in a discovery cohort of IL10^−/− mice. Sera were collected from IL10^−/− mice at age 30, 58, 86, 114 and 128-days and subjected to miRNA profiling. (A) Hierarchical clustering showing the relative expression levels of the 14 deregulated miRNAs in each sample. (B) Expression profiles of miRNAs in colitic mice (D128) compared to the same mice before they develop colitis (D30). The average expression of each miRNA in non-colitic mice was set to 1. (C) Age-dependent representation of the expression profiles of the 14 deregulated miRNAs in the sera of IL10^−/− mice. Seven were increased (left panel), and seven were decreased (right panel). (D) The expression levels of these differentially expressed miRNAs were analyzed in sera from WT mice. Data are given as the means +/− S.E.M. (n = 6).