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. 2017 May 31;7:2520. doi: 10.1038/s41598-017-02782-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation analysis between principal coordinates from the new miRNA signature and intestinal inflammation marker CRP. (A) Correlation analysis between principal coordinate 5 from the miRNA signature in IL10^−/− D98 mice and intestinal inflammation marker CRP. (B) Correlation analysis between principal coordinate 1 from the miRNA signature in anti-TNFα treated IL10^−/− D98 mice and intestinal inflammation marker CRP (n = 9). Significance was determined using an unpaired t-test (*p < 0.05; and **p < 0.01) compared to mice with the colitic-type signature.