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. 2017 May 31;7:2520. doi: 10.1038/s41598-017-02782-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miRNA signature in UC patients. The expression levels of 9 deregulated miRNAs were assesses by qPCR in UC patients. (A) Heatmap showing the relative fold changes over controls of the 9 miRNAs in each sample. (B) PCoA of the bray curtis distance of miRNA expression in sera from non-colitic mice (in blue), colitic mice (in red), Ulcerative colitis (UC) patients and healthy control. (C) kNN (k-Nearest Neighbour) classifier were applied using mice samples (both colitic and non colitic) as discovery cohort and human samples (both UC and controls) as test cohort. Prediction rates of disease state using the previously identified miRNA signature is shown.