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. 2017 May 31;7:2549. doi: 10.1038/s41598-017-02352-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Blocking ITGαVβ3 attenuates migration of HSPCs. (a) Individual frames of 15 minutes time-laps microscopy studies of migrating and interacting cells on ECMs. Bar = 5 µm. (b) Individual frames of 25 minutes time-laps microscopy of a non-migrating cell and a migrating cell forming no-migrating phenotype (asterisk). Bar = 5 µm. (c) Cells were cultured 5 days on ECMs and incubated one hour with α-ITGαVβ3 or IgG. Trajectory plots depict migration of 25 HSPCs for 45 minutes. (d) Box-and-whiskers plots presenting accumulated distance and velocity of 77 HSPCs migration tracks monitored for 45 minutes pre-incubated 1 hour with α-ITGαVβ3 or IgG. Lines show 25th – 75th percentiles, horizontal line represents median and plus represents mean value. two-tailed t-test.; *p < 0.05, **p < 0.01, ***p < 0.001.