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. 2017 May 31;7:2510. doi: 10.1038/s41598-017-02820-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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1e compound and 17β- estradiol accelerate wound healing. (a) In vivo BLI: round wound area photon emission quantification at indicated time point in MITO-Luc mice. Each bar represents the mean ratio versus time = 0 h +/− SEM of photon emission measured in 2 animals/group. (**p < 0.01 vs 0 h, ANOVA followed by Bonferroni’s test for multiple comparisons). (b) Hematoxylin-eosin representative staining of wound section at 10 days after the indicated treatments. The histoscore value for granulation tissue (fibrosis) is shown as mean, each histoscore consists of 4 random fields/groups, the criteria for the assignation of histoscore value are: 1 = wound bed partially covered with granulation tissue; 2 = thin granulation over the whole wound bed; 3 = thick granulation over the whole wound bed. Bar = 2 mm.