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. 2017 May 31;7:2510. doi: 10.1038/s41598-017-02820-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of NCE on ER transcriptional activity in living ERE-Luc mice: dose- response. (a) Optical imaging of ERE-Luc mice at 0 and 6 hours after treatment with the indicated dosages of 1e compound. Photos portray whole body (ventral view) of a representative individual in a pseudocolor image indicating the intensity of photon emission from the different body areas. (b) In vivo BLI: quantification of photon emission whole body at 0 and 6 hours after injection of 1e at indicated dosages. (c) Optical imaging of ERE-Luc mice at 0 and 6 hours after treatment with the indicated dosages of 1f compound. Photos portray whole body (ventral view) in a pseudocolor image processed to indicating the intensity of photon emission from the different body areas of a representative animal for each group. (d) Whole body photon emission quantification at 0 and 6 hours after 1f treatment at indicated doses. Bars correspond to mean +/− SEM (n = 4).