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. 2017 May 31;7:2554. doi: 10.1038/s41598-017-02818-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PepR-NIR750 specifically binds CXCR4 expressing cells. B16-CXCR4 and PES43 tumor cell lines expressing high CXCR4 levels and FB1 cells expressing very low CXCR4 levels were plated on glass coverslips and labeled with PepR-NIR750 or VivoTag-S 750 alone (100 nM) for 1 h at 37 °C; nuclei were labeled with DAPI and the fluorescence was observed by confocal microscope (LSM 510 Zeiss). PepR-NIR750 binds to B16-CXCR4 and PES43 cells but not to FB-1 cells whereas VivoTag-S 750 signal is not detected in all cell lines tested.