Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 May 31;7:2554. doi: 10.1038/s41598-017-02818-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

PepR-NIR750 detects lung metastases reduction induced by Peptide R treatment. CD-1 nu/nu athymic mice bearing PES43-derived lung metastases were treated with PBS (control group) or Peptide R (2 mg/Kg) 5 days/week for 2 weeks. 3 weeks later mice were i.v. injected with PepR-NIR750 or VivoTag-S 750 alone and total body imaged after 24 h with FMT4000. (A) PepR-NIR750 signal is detectable in mice bearing lung metastases (upper and middle left panels) while no signal was revealed with VivoTag-S 750 alone (upper and middle right panels). Healthy lungs are not imaged by PepR-NIR750 (lower panel). (B) In vivo imaging of mice bearing lung metastases treated and not treated with Peptide R using Pep-R-NIR750. Peptide R causes a strong reduction of PepR-NIR750 signal (65%) respect to control group as observed 24 hours after its injection. (C) After 24 h the mice were euthanized, the lungs snap frozen and then were 5 µm sliced at cryostat microtome. Slides of PepR-NIR750 or VivoTag-S 750 were imaged at fluorescence microscope Axioscope A.1.