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. 2017 May 31;7:2502. doi: 10.1038/s41598-017-02768-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mer is required to prevent CySC/CC overproliferation in the germ cell-depleted testis. (A–C) The apical tip of the testis from nos > bam stained for Tj, FasIII, and phosphorylated histone H3 (pH3). The testis apical region is marked by white lines. Terminal epithelium (TE). Bar, 50 µm. (D and E) The apical tip of the testis from Mer ^ts1 nos > bam. Overproliferated Tj⁺ cells stained for FasIII (D’ and E’). Arrowheads indicate mitotic somatic cells. (F) Summary of the testis phenotype upon depletion of germ cells in the wild-type or Mer ^ts1 background. Types I–IV correspond to the designations in A–E. n ≥ 27 testes for each data point. (G) The mitotic index in testes expressing bam in a wild-type or Mer ^ts1 mutant background. N = 30 testes for each data point. (H) The number of Tj⁺ cells in wild-type and Mer ^ts1 background after induction of germ cell loss by expression of bam upon eclosion. N ≥ 10 testes for each data point. p values were obtained using the Student’s t test (two-tailed) by comparing to control at corresponding time points.