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. 2017 Jun 1;8:626. doi: 10.3389/fimmu.2017.00626

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Copyright © 2017 Graubardt, Vugman, Mouhadeb, Caliari, Pasmanik-Chor, Reuveni, Zigmond, Brazowski, David, Chappell-Maor, Jung and Varol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Variable expression of apoptotic cell bridging molecules and receptors between Ly6C^hi monocytes, monocyte-derived macrophages (MoMF), and Kupffer cell (KC). Heat map analysis generated using Partek Genomics Suite version 6.6 (Partek, St. Louis, MO, USA). The heat maps show the fold-change gene-expression differences of bridge molecules (upper panel) and macrophage receptors (lower panel) involved with apoptotic cell clearance. The heat map presents comparison between Ly6C^hi monocytes [acetaminophen-induced liver injury (AILI) 24 h], MoMF (AILI 72 h), and KC (steady state and AILI 72 h). Color legend is presented at the bottom of the figure. Statistical significance for specific genes is mentioned as p-value in the text and was analyzed by ANOVA followed by Bonferroni’s multiple comparison test. These results were analyzed out of a published database (22).