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. Author manuscript; available in PMC: 2017 Aug 28.
Published in final edited form as: Sci Signal. 2017 Feb 28;10(468):eaag2298. doi: 10.1126/scisignal.aag2298

Figure 6. Transcriptional Feedback Control of Selective Autophagy.

Figure 6

Several parallel feedback loops couple sensing of organelle damage with transcriptional regulation of selective autophagy genes. Under basal conditions, KEAP1 binds to and targets NRF2 for proteasomal degradation. Protein aggregates and dysfunctional mitochondria accumulate p62, which binds to and sequesters KEAP1 to free NRF2 and activate its transcriptional activity. NRF2 targets many selective autophagy genes to degrade p62-tagged cargo. Similarly, TFEB translocates to the nucleus in response to mitochondrial and lysosomal stresses to transcribe selective autophagy, mitochondrial, and lysosomal genes.