Table 2.
Characteristics of included studies.
| Control group | Study group | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Authors | Year | Protocol used | ART | Number | Mean age (years) | Drug 1 | Name | Startig doe (IU/daily) | Drug 2 | name | Startig doe (IU/daily) | Drop out | Numr | Mean age (years) | Drug 1 | name | Startig doe (IU/daily) | Drug 2 | name | Startig doe (IU/daily) | Drop out |
| Gerli | 1993 | Gonadotropin-releasing hormone (GnRH) agonist | In vitro fertilization (IVF) | 17 | 30.9 | FSH | Metrodin | 225 | 2 | 15 | 31.4 | hMG | Pergonal | 225 | 1 | ||||||
| Daya | 1995 | GnRH agonist | IVF | 115 | 33.5 | FSH | Metrodin | 150 | 117 | 33.2 | hMG | Pergonal | 150 | ||||||||
| Westergaard | 1996 | GnRH agonist | IVF | 104 | 31.0 | FSH | Fertinorm | 225 | 114 | 32.0 | hMG | Pergonal | 225 | ||||||||
| Jansen | 1998 | None | IVF | 47 | 32.0 | FSH | Puregon | 150 | 32 | 31.1 | hMG | Humegon | 225 | ||||||||
| Filicori | 1999 | GnRH agonist | IVF | 10 | 32.0 | FSH | Metrodin | 300 | 0 | 10 | 33.0 | FSH | Metrodin | 300 | hCG | Profasi | 50 | 0 | |||
| Sills | 1999 | GnRH agonist | IVF | 17 | 35.4 | FSH | Fertinex | 14 | 36.7 | FSH | Fertinex | LH | Lhadi | 75 | |||||||
| Balasch | 2001 | GnRH agonist | IVF | 14 | 33.6 | FSH | Gonal F | 150 | 1 | 16 | 34.8 | FSH | Gonal F | 150 | LH | Luveris | 75 | 1 | |||
| De Placido | 2001 | GnRH agonist | IVF | 40 | 30.1 | FSH | Gonal F | 300 | 0 | 20 | 31.6 | FSH | Gonal F | 150 | hMG | Menogon | 150 | 0 | |||
| Filicori | 2001 | GnRH agonist | IVF | 25 | 32.0 | FSH | Metrodin | 150 | 0 | 25 | 33.0 | hMG | Menogon | 150 | 0 | ||||||
| Gordon | 2001 | GnRH agonist | IVF | 69 | 33.5 | FSH | Puregon | 225 | 12 | 59 | 33.5 | hMG | Humegon | 75 | 6 | ||||||
| Ng | 2001 | GnRH agonist | IVF | 20 | 33.5 | FSH | Gonal F | 300 | 20 | 32.0 | hMG | Pergonal | 300 | ||||||||
| Strehler | 2001 | GnRH antagonist | IVF | 248 | 32.3 | FSH | Gonal F | 300 | 259 | 31.8 | hMG | Menogon | 300 | ||||||||
| Westergaard | 2001 | GnRH agonist | IVF | 190 | FSH | Gonal F | 225 | 2 | 189 | hMG | Menogon | 225 | 3 | ||||||||
| Filicori | 2002 | GnRH agonist | IVF | 30 | 31.9 | FSH | Metrodin | 150 | 90 | 32.7 | FSH | Metrodin | 150 | LH | Menogon | 75 | |||||
| Ismail | 2002 | GnRH agonist | IVF | 75 | 33.2 | FSH | Fostimon | 150 | 78 | 34.3 | hMG | Menogon | 150 | ||||||||
| Lisi | 2002 | GnRH agonist | IVF | 331 | 34.7 | FSH | Gonal F | 150 | 122 | 34.8 | FSH | Gonal F | 150 | LH | Luveris | 75 | |||||
| Filicori a | 2003 | GnRH agonist | Intrauterine insemination (IUI) | 25 | 31.9 | FSH | Gonal F | 150 | 25 | 32.6 | hMG | Menogon | 150 | ||||||||
| Filicori b | 2003 | GnRH agonist | IVF | 50 | 25.9 | FSH | Gonal F | 150 | 14 | 50 | 27 | hMG | Menopur | 150 | 12 | ||||||
| Ku | 2003 | GnRH agonist | IVF | 19 | 34.6 | FSH | Metrodin | 300 | 26 | 33.0 | FSH | Metrodin | 300 | hMG | Pergonal | 75 | |||||
| Marrs | 2003 | GnRH agonist | IVF | 219 | 31.9 | FSH | Gonal F | 225 | 212 | 32.4 | FSH | Gonal F | 225 | LH | Luveris | 150 | |||||
| Acevedo | 2004 | GnRH antagonist | IVF | 20 | 23.0 | FSH | Gonal F | 225 | 22 | 26.0 | FSH | Gonal F | 225 | LH | Luveris | 75 | |||||
| Cédrin-Durnerin | 2004 | GnRH antagonist | IVF | 96 | 31.7 | FSH | Gonal F | 150 | 2 | 107 | 31.4 | FSH | Gonal F | 150 | LH | Luveris | 75 | 0 | |||
| De Placido | 2004 | GnRH agonist | IVF | 46 | 30.4 | FSH | Gonal F | 150 | 46 | 30.0 | FSH | Gonal F | 150 | LH | Luveris | 75 | |||||
| Ferraretti | 2004 | GnRH agonist | IVF | 104 | 31.7 | FSH | Gonal F | 225 | 2 | 54 | 31.5 | FSH | Gonal F | 225 | LH | Luveris | 75 | 4 | |||
| Ferraretti | 2004 | GnRH agonist | IVF | 104 | 31.7 | FSH | Gonal F | 225 | 2 | 22 | 32.0 | FSH | Gonal F | 225 | hMG | Menogon | |||||
| Humaidan | 2004 | GnRH agonist | IVF | 115 | 30.5 | FSH | Puregon | 150 | 116 | 30.8 | FSH | Puregon | 150 | LH | Luveris | ||||||
| Loutradis | 2004 | GnRH agonist | IVF | 106 | 37.3 | FSH | 200 | 98 | 38.1 | FSH | 200 | hMG | |||||||||
| De Placido | 2005 | GnRH agonist | IVF | 58 | 30.4 | FSH | Gonal F | 225 | 57 | 31.5 | FSH | Gonal F | 225 | LH | Luveris | 150 | |||||
| Drakakis | 2005 | GnRH agonist | IVF | 22 | 33.0 | FSH | Puregon | 200 | 24 | 32.4 | FSH | Puregon | 200 | hMG | Menogon | 75 | |||||
| Filicori | 2005 | GnRH agonist | IVF | 24 | 33.4 | FSH | Puregon | 225 | 24 | 33.8 | FSH | Puregon | 225 | hCG | Gonasi | 200 | |||||
| Gómez-Palomares | 2005 | GnRH antagonist | IVF | 58 | 39.0 | FSH | Gonal F | 225 | hMG | HMG-Lepori | 75 | 4 | 36 | 38.8 | FSH | Gonal F | 300 | LH | Luveris | 75 | 2 |
| Griesinger | 2005 | GnRH antagonist | IVF | 65 | 30.5 | FSH | Gonal F | 150 | 11 | 62 | 30.3 | FSH | Gonal F | 150 | LH | Luveris | 75 | 6 | |||
| Hugues | 2005 | None | IVF | 30 | 29.9 | FSH | Gonal F | 150 | 0 | 117 | 29.3 | FSH | Gonal F | 150 | LH | Luveris | 150–300 | 1 | |||
| Fabregues | 2006 | GnRH agonist | IVF | 60 | 38.2 | FSH | Gonal F | 150 | 5 | 60 | 38.4 | FSH | Gonal F | 150 | LH | Luveris | 150 | 5 | |||
| Levi-Setti | 2006 | GnRH antagonist | IVF | 20 | 32.3 | FSH | Gonal F | 225 | 4 | 20 | 32.2 | FSH | Gonal F | 150 | LH | Luveris | 75 | 2 | |||
| Tarlatzis | 2006 | GnRH agonist | IVF | 59 | 30.3 | FSH | Gonal F | 150 | 2 | 55 | 30.5 | FSH | Gonal F | 150 | LH | Luveris | 75 | 0 | |||
| Berkkanoglu | 2007 | GnRH agonist | IVF | 51 | 34.9 | FSH | Gonal F | 600 | 46 | 36.3 | FSH | Gonal F | 600 | LH | Luveris | 75 | |||||
| Berkkanoglu | 2007 | GnRH agonist | IVF | 51 | 34.9 | FSH | Gonal F | 600 | 48 | 35.2 | FSH | Gonal F | 600 | hCG | Ovitrelle | 75 | |||||
| Demirol | 2007 | None | IUI | 161 | 30.4 | FSH | Gonal F | 150 | 0 | 80 | 30.8 | hMG | 150 | 0 | |||||||
| Ziebe | 2007 | GnRH agonist | IVF | 368 | FSH | 225 | 363 | hMG | 225 | ||||||||||||
| Barrenetxea | 2008 | GnRH agonist | IVF | 42 | 41.8 | FSH | Gonal F | 300 | 42 | 42.1 | FSH | Gonal F | 300 | LH | Luveris | 150 | |||||
| Bosch | 2008 | GnRH antagonist | IVF | 140 | 33.4 | FSH | Gonal F | 225 | 20 | 140 | 33.2 | hMG | Menopur | 225 | 23 | ||||||
| Hompes | 2008 | GnRH antagonist | IVF | 317 | 32.0 | FSH | Gonal F | 150 | 15 | 312 | 31.7 | hMG | Menopur | 150 | 19 | ||||||
| Nyboeandersen | 2008 | GnRH agonist | IVF | 261 | 31.8 | FSH | Gonal F | 150 | 0 | 265 | 31.7 | FSH | Gonal F | 150 | LH | Luveris | 75 | 0 | |||
| Blockeel | 2009 | GnRH antagonist | IVF | 35 | 30.0 | FSH | Puregon | 225 | 3 | 35 | 29.0 | FSH | Puregon | 225 | hCG | Pregnyl | 200 | 6 | |||
| Check | 2009 | GnRH antagonist | IVF | 35 | 35.1 | FSH | 300 | 1 | 35 | 33.6 | FSH | 300 | hCG | 25 | 3 | ||||||
| Drakakis | 2009 | GnRH agonist | IVF | 58 | 36.4 | FSH | Gonal F | 200 | rhCG | 200 | 56 | 37.3 | FSH | Gonal F | 200 | LH | |||||
| Matorras | 2009 | GnRH agonist | IVF | 68 | 36.7 | FSH | Gonal F | 300 | 3 | 63 | 36.6 | FSH | Gonal F | 300 | LH | Luveris | 150 | 0 | |||
| Melo | 2010 | GnRH agonist | IVF | 346 | 24.9 | FSH | Gonal F | 225 | 333 | 23.9 | hMG | Menopur | 225 | ||||||||
| Pacchiarotti | 2010 | GnRH antagonist | IVF | 60 | hMG | Menopur | 225 | 2 | 62 | FSH | Pergoveris | 225 | LH | Luveris | 8 | ||||||
| Bosch | 2011 | GnRH antagonist | IVF | 314 | 34.6 | FSH | Gonal F | 225 | 50 | 311 | 34.7 | FSH | Gonal F | 150 | LH | Luveris | 75 | 56 | |||
| Caserta | 2011 | GnRH agonist | IVF | 501 | 34.8 | FSH | Gonal F | 150 | 498 | 34.3 | FSH | Gonal F | 150 | LH | |||||||
| Kokac | 2011 | GnRH agonist | IUI | 24 | 29.5 | FSH | Gonal F | 75 | 25 | 28.8 | hMG | Merional | 75 | ||||||||
| Pezzuto | 2011 | GnRH agonist | IVF | 40 | 34.0 | FSH | Puregon | 225 | 40 | 35.0 | FSH | Puregon | 225 | LH | Luveris | 75 | |||||
| Sagnella | 2011 | IUI | 262 | 35.4 | FSH | Gonal F | 150 | 23 | 261 | 35.0 | hMG | Meropur | 75–150 | 5 | |||||||
| Barberi | 2012 | GnRH agonist | IVF | 11 | 32.3 | FSH | Gonal F | 150 | 10 | 9 | 34.1 | FSH | Gonal F | 150 | LH | Luveris | 75 | 2 | |||
| Devroy | 2012 | GnRH antagonist | IVF | 375 | 30.4 | FSH | Puregon | 150 | 59 | 374 | 30.8 | hMG | Menopur | 150 | 69 | ||||||
| Lisi | 2012 | GnRH agonist | IVF | 75 | 32.8 | FSH | Gonal F | 150 | 75 | 33.6 | FSH | Gonal F | 150 | LH | 75 | ||||||
| Madani | 2012 | GnRH antagonist | IVF | 26 | 39.2 | FSH | Gonal F | 300 | 0 | 47 | 38.9 | FSH | Gonal F | 300 | hCG | Pregnyl | 200 | 0 | |||
| Revelli | 2012 | GnRH antagonist | IVF | 266 | 39.2 | FSH | Gonal F | 300 | 27 | 264 | 39.4 | FSH | Gonal F | 150 | LH | Luveris | 150 | 29 | |||
| Thuesen | 2012 | GnRH agonist | IVF | 16 | 31.5 | FSH | Puregon | 150 | 2 | 46 | 32.6 | FSH | Puregon | 150 | hCG | Predalon | 100 | 5 | |||
| Ye | 2012 | GnRH agonist | IVF | 64 | 36.2 | FSH | Gonal F | 225 | 63 | 36.2 | hMG | Menopur | 225 | ||||||||
| Konig | 2013 | GnRH antagonist | IVF | 128 | 37.9 | FSH | Gonal F | 225 | 17 | 125 | 38.0 | FSH | Gonal F | 225 | LH | Luveris | 150 | 14 | |||
| Rashidi | 2013 | IUI | 132 | 28.7 | FSH | Gonal F | 75 | 3 | 127 | 29.1 | hMG | Menogon | 75 | 1 | |||||||
| Thuesen | 2013 | GnRH agonist | IVF | 16 | 32.3 | FSH | Puregon | 150 | 0 | 46 | 32.3 | FSH | Puregon | 150 | hCG | Predalon | 100 | 0 | |||
| Razi | 2014 | GnRH agonist | IVF | 20 | 31.3 | FSH | Gonal F | 150 | 0 | 20 | 31.8 | FSH | Gonal F | 150 | LH | Luveris | 75 | 0 | |||
| Behre | 2015 | GnRH agonist | IVF | 99 | 37.6 | FSH | Gonal F | 300 | 1 | 103 | 37.4 | FSH | Gonal F | 300 | LH | Luveris | 150 | 2 | |||
| Moro | 2015 | none | IUI | 289 | 37.9 | hMG | Meropur | 150 | 5 | 290 | 38.4 | FSH | Gonal F | 150 | LH | Luveris | 150 | 13 | |||
| Vuong | 2015 | GnRH antagonist | IVF | 120 | 38.0 | FSH | Gonal F | 300 | 11 | 120 | 38.0 | FSH | Gonal F | 300 | LH | Pergoveris | 150 | 18 | |||
| Yilmaz | 2015 | GnRH agonist | IVF | 87 | 29.0 | FSH | Puregon | 50 | 30.3 | FSH | Puregon | LH | Luveris | 75 | |||||||
| Younis | 2016 | GnRH antagonist | IVF | 30 | 38.6 | FSH | Gonal F | 300 | 6 | 32 | 38.9 | FSH | Gonal F | 300 | LH | Luveris | 150 | 5 | |||