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. 2017 May 24;7(5):170042. doi: 10.1098/rsob.170042

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© 2017 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — A working model for the role of UBLCP1 in 26S proteasome assembly. (a) A working model for proteasome regulation by UBLCP1. UBLCP1 selectively binds to RP precursor containing p28 and PAAF1. Rpn1 recruits UBLCP1 to dephosphorylate Rpt1. As a result, UBLCP1 impairs the RP–CP association, but preserves RP integrity. Arrangement of coloured proteasome base subunits is viewed from the top. (b) Schematic of reported Rpn1-interacting proteins. (c) A working model for UBLCP1 as a phosphatase of Rpt1. UBLCP1 dephosphorylates Rpt1 by interacting with the C-terminal of Rpn1. CC, coiled-coil.