Fig. 4.

Human endothelial colony-forming cells-conditioned medium (ECFC-CM) protects against renal I/R injury. A: serum creatinine for 2 days following I/R or sham surgery (n = 3) in vehicle (n = 7)- and ECFC-CM-treated rats (n = 7). B: representative photomicrographs of PAS-stained kidney sections following 2 days of recovery from renal I/R. Significant necrotic debris and tubular damage are present in vehicle-treated rat kidney 2 days postsurgery (black arrows). Magnification is shown. Tissue injury score is shown in C. D: KIM-1 mRNA expression in sham, vehicle-, or ECFC-CM-treated rats. Data are means ± SE. n.d., Not detectable. *P < 0.05 in ECFC-CM-treated relative to vehicle-treated rats by Student’s t-test.