Table 2.
Exocytosis protein expression in type 2 diabetic humans and rodents
| Protein | Tissue | Protein Levels in T2D Humans | Protein Levels in T2D Rodents | Ref. No(s). |
|---|---|---|---|---|
| DOC2B | Islets | Decreased | ND | 6 |
| Munc13-1 | Islets | Decreased | Decreased in diabetic GK and obese Zucker fa/fa rats | 83, 100 |
| Munc18-1 | Islets | Decreased | ND | 78, 83 |
| Munc18c | Islets; skeletal muscle; adipose | All decreased | Decreased in diabetic GK rats | 9, 28, 30, 72, 83 |
| SNAP25 | Islets | Decreased | Decreased in diabetic GK rats | 28, 72, 83 |
| STX1A | Islets | Decreased SNP (D68D, T to C) correlates to age at onset and insulin requirement in T2D | Decreased in hyperglycemic GK rats | 3, 72, 78, 83, 115 |
| STX4 | Islets, Skeletal muscle | Decreased in both tissues | ND | 9, 78 |
| Synaptophysin | Islets | Decreased | ND | 83 |
| Synaptotagmin 4, 7, and 11 | Islets | Decreased | ND | 3 |
| VAMP2 | Islets | Decreased | Decreased in diabetic GK rats | 28, 83 |
DOC2B, double C2-domain protein B; ND, not determined; PM, plasma membrane; SNP, single nucleotide polymorphism; GK, Goto-Kakizaki; VAMP2, vesicle-associated membrane protein 2. Note: presented in alphabetical order by protein name.