Fig. 2.
A: core body temperature (TCORE; top traces) and ambient temperature (TAMB; bottom traces) records from 2 awake, free-behaving rats during the onset of the hypothermia induced by intracerebroventricular (icv) administration of the A1 adenosine receptor (A1AR) agonist N6-cyclohexyladenosine (CHA) at a TAMB of 15°C. Note that TCORE declines under conditions of cold TAMB, consistent with an inhibition of thermogenesis. B: TCORE and TAMB records from 2 different intracerebroventricular CHA-treated rats during skin rewarming with a TAMB of 20°C. Note that TCORE continues to decline under conditions of a TAMB of 20°C. C: TCORE and TAMB records from 2 different intracerebroventricular CHA-treated rats during skin rewarming with a TAMB of 27°C. Note that TCORE increases under conditions of a TAMB of 27°C and that the rise in TCORE was time locked to the increase in TAMB.